Modeling drug-induced liver injury and screening for anti-hepatofibrotic compounds using human PSC-derived organoids

Preclinical models that can accurately predict the toxicity and efficacy of candidate drugs to human liver tissue are in urgent need. Human liver organoid (HLO) derived from human pluripotent stem cells offers a possible solution. Herein, we generated HLOs, and demonstrated the utility of these HLOs...

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Detalles Bibliográficos
Autores principales: Wu, Xiaoshan, Jiang, Dacheng, Yang, Yi, Li, Shuang, Ding, Qiurong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981852/
https://www.ncbi.nlm.nih.gov/pubmed/36864321
http://dx.doi.org/10.1186/s13619-022-00148-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9981852/
https://www.ncbi.nlm.nih.gov/pubmed/36864321
http://dx.doi.org/10.1186/s13619-022-00148-1

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