Human monocarboxylate transporters accept and relay protons via the bound substrate for selectivity and activity at physiological pH

Human monocarboxylate/H(+) transporters, MCT, facilitate the transmembrane translocation of vital weak acid metabolites, mainly l-lactate. Tumors exhibiting a Warburg effect rely on MCT activity for l-lactate release. Recently, high-resolution MCT structures revealed binding sites for anticancer dru...

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Detalles Bibliográficos
Autores principales: Geistlinger, Katharina, Schmidt, Jana D R, Beitz, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982067/
https://www.ncbi.nlm.nih.gov/pubmed/36874278
http://dx.doi.org/10.1093/pnasnexus/pgad007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982067/
https://www.ncbi.nlm.nih.gov/pubmed/36874278
http://dx.doi.org/10.1093/pnasnexus/pgad007

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