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Human monocarboxylate transporters accept and relay protons via the bound substrate for selectivity and activity at physiological pH
Human monocarboxylate/H(+) transporters, MCT, facilitate the transmembrane translocation of vital weak acid metabolites, mainly l-lactate. Tumors exhibiting a Warburg effect rely on MCT activity for l-lactate release. Recently, high-resolution MCT structures revealed binding sites for anticancer dru...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982067/ https://www.ncbi.nlm.nih.gov/pubmed/36874278 http://dx.doi.org/10.1093/pnasnexus/pgad007 |