Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Astrocytes from Humanized Targeted Replacement Mice

Apolipoprotein E4 (APOE4) genotype and sex are significant risk factors for Alzheimer's disease (AD), with females demonstrating increased risk modulated by APOE genotype. APOE is predominantly expressed in astrocytes, however, there is a lack of comprehensive assessments of sex differences in...

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Detalles Bibliográficos
Autores principales: Mhatre-Winters, Isha, Eid, Aseel, Han, Yoonhee, Tieu, Kim, Richardson, Jason R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
The Role of Glial Cells in the Nervous System in Health and Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982390/
https://www.ncbi.nlm.nih.gov/pubmed/36604975
http://dx.doi.org/10.1177/17590914221144549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982390/
https://www.ncbi.nlm.nih.gov/pubmed/36604975
http://dx.doi.org/10.1177/17590914221144549

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