Nuclear Fructose‐1,6‐Bisphosphate Inhibits Tumor Growth and Sensitizes Chemotherapy by Targeting HMGB1

Metabolites are important for cell fate determination. Fructose‐1,6‐bisphosphate (F1,6P) is the rate‐limiting product in glycolysis and the rate‐limiting substrate in gluconeogenesis. Here, it is discovered that the nuclear‐accumulated F1,6P impairs cancer cell viability by directly binding to high...

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Detalles Bibliográficos
Autores principales: Li, Yeyi, Fu, Yuan, Zhang, Yan, Duan, Bilian, Zhao, Yanli, Shang, Man, Cheng, Ying, Zhang, Kai, Yu, Qiujing, Wang, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982576/
https://www.ncbi.nlm.nih.gov/pubmed/36642839
http://dx.doi.org/10.1002/advs.202203528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982576/
https://www.ncbi.nlm.nih.gov/pubmed/36642839
http://dx.doi.org/10.1002/advs.202203528

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