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Nuclear Fructose‐1,6‐Bisphosphate Inhibits Tumor Growth and Sensitizes Chemotherapy by Targeting HMGB1
Metabolites are important for cell fate determination. Fructose‐1,6‐bisphosphate (F1,6P) is the rate‐limiting product in glycolysis and the rate‐limiting substrate in gluconeogenesis. Here, it is discovered that the nuclear‐accumulated F1,6P impairs cancer cell viability by directly binding to high...
Autores principales: | Li, Yeyi, Fu, Yuan, Zhang, Yan, Duan, Bilian, Zhao, Yanli, Shang, Man, Cheng, Ying, Zhang, Kai, Yu, Qiujing, Wang, Ting |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982576/ https://www.ncbi.nlm.nih.gov/pubmed/36642839 http://dx.doi.org/10.1002/advs.202203528 |
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