Effect of Fc core fucosylation and light chain isotype on IgG1 flexibility

N-glycosylation plays a key role in modulating the bioactivity of monoclonal antibodies (mAbs), as well as the light chain (LC) isotype can influence their physicochemical properties. However, investigating the impact of such features on mAbs conformational behavior is a big challenge, due to the ve...

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Detalles Bibliográficos
Autores principales: Saporiti, Simona, Laurenzi, Tommaso, Guerrini, Uliano, Coppa, Crescenzo, Palinsky, Wolf, Benigno, Giulia, Palazzolo, Luca, Ben Mariem, Omar, Montavoci, Linda, Rossi, Mara, Centola, Fabio, Eberini, Ivano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982779/
https://www.ncbi.nlm.nih.gov/pubmed/36869088
http://dx.doi.org/10.1038/s42003-023-04622-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982779/
https://www.ncbi.nlm.nih.gov/pubmed/36869088
http://dx.doi.org/10.1038/s42003-023-04622-7

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