One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines

[Image: see text] Herein, we report a one-pot, chemoenzymatic process for the synthesis of enantioenriched C(1)-allylated tetrahydroisoquinolines. This transformation couples a monoamine oxidase (MAO-N)-catalyzed oxidation with a metal catalyzed allylboration, followed by a biocatalytic deracemizati...

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Detalles Bibliográficos
Autores principales: Sangster, Jack J., Ruscoe, Rebecca E., Cosgrove, Sebastian C., Mangas-Sánchez, Juan, Turner, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983016/
https://www.ncbi.nlm.nih.gov/pubmed/36790859
http://dx.doi.org/10.1021/jacs.2c09176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983016/
https://www.ncbi.nlm.nih.gov/pubmed/36790859
http://dx.doi.org/10.1021/jacs.2c09176

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