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Activation of the Hedgehog signaling pathway leads to fibrosis in aortic valves
BACKGROUND: Fibrosis is a pathological wound healing process characterized by excessive extracellular matrix deposition, which interferes with normal organ function and contributes to ~ 45% of human mortality. Fibrosis develops in response to chronic injury in nearly all organs, but the a cascade of...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983197/ https://www.ncbi.nlm.nih.gov/pubmed/36864465 http://dx.doi.org/10.1186/s13578-023-00980-1 |