JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors

BACKGROUND: Rheumatoid arthritis (RA) is characterized by chronic inflammation and resultant cartilage/bone destruction because of aberrantly activated osteoclasts. Recently, novel treatments with several Janus kinase (JAK) inhibitors have been shown to successfully ameliorate arthritis-related infl...

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Detalles Bibliográficos
Autores principales: Yari, Shinya, Kikuta, Junichi, Shigyo, Hotaka, Miyamoto, Yu, Okuzaki, Daisuke, Furusawa, Yuki, Minoshima, Masafumi, Kikuchi, Kazuya, Ishii, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983229/
https://www.ncbi.nlm.nih.gov/pubmed/36869390
http://dx.doi.org/10.1186/s41232-023-00268-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983229/
https://www.ncbi.nlm.nih.gov/pubmed/36869390
http://dx.doi.org/10.1186/s41232-023-00268-4

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