SARS-COV-2 Coronavirus Papain-like Protease PLpro as an Antiviral Target for Inhibitors of Active Site and Protein–Protein Interactions

The papain-like protease PLpro of the SARS-CoV-2 coronavirus is a multifunctional enzyme that catalyzes the proteolytic processing of two viral polyproteins, pp1a and pp1ab. PLpro also cleaves peptide bonds between host cell proteins and ubiquitin (or ubiquitin-like proteins), which is associated wi...

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Detalles Bibliográficos
Autores principales: Ershov, P. V., Yablokov, E. O., Mezentsev, Y. V., Chuev, G. N., Fedotova, M. V., Kruchinin, S. E., Ivanov, A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2023
Materias:
Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984130/
https://www.ncbi.nlm.nih.gov/pubmed/36883182
http://dx.doi.org/10.1134/S0006350922060082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984130/
https://www.ncbi.nlm.nih.gov/pubmed/36883182
http://dx.doi.org/10.1134/S0006350922060082

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