Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative

During cotranslational translocation, the signal peptide of a nascent chain binds Sec61 translocon to initiate protein transport through the endoplasmic reticulum (ER) membrane. Our cryo–electron microscopy structure of ribosome-Sec61 shows binding of an ordered heterotetrameric translocon-associate...

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Detalles Bibliográficos
Autores principales: Pauwels, Eva, Shewakramani, Neesha R., De Wijngaert, Brent, Camps, Anita, Provinciael, Becky, Stroobants, Joren, Kalies, Kai-Uwe, Hartmann, Enno, Maes, Piet, Vermeire, Kurt, Das, Kalyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984176/
https://www.ncbi.nlm.nih.gov/pubmed/36867692
http://dx.doi.org/10.1126/sciadv.adf0797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984176/
https://www.ncbi.nlm.nih.gov/pubmed/36867692
http://dx.doi.org/10.1126/sciadv.adf0797

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