Cryo-EM structures of human SPCA1a reveal the mechanism of Ca(2+)/Mn(2+) transport into the Golgi apparatus

Secretory pathway Ca(2+)/Mn(2+) ATPase 1 (SPCA1) actively transports cytosolic Ca(2+) and Mn(2+) into the Golgi lumen, playing a crucial role in cellular calcium and manganese homeostasis. Detrimental mutations of the ATP2C1 gene encoding SPCA1 cause Hailey-Hailey disease. Here, using nanobody/megab...

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Detalles Bibliográficos
Autores principales: Chen, Zhenghao, Watanabe, Satoshi, Hashida, Hironori, Inoue, Michio, Daigaku, Yasukazu, Kikkawa, Masahide, Inaba, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984183/
https://www.ncbi.nlm.nih.gov/pubmed/36867705
http://dx.doi.org/10.1126/sciadv.add9742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984183/
https://www.ncbi.nlm.nih.gov/pubmed/36867705
http://dx.doi.org/10.1126/sciadv.add9742

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