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Limited impacts of biogenetic messaging on neural correlates of cognitive control and beliefs about depression

During the past 60 years, perceptions about the origins of mental illness have shifted toward a biomedical model, depicting depression as a biological disorder caused by genetic abnormalities and/or chemical imbalances. Despite benevolent intentions to reduce stigma, biogenetic messages promote prog...

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Autores principales: Lamontagne, Steven J., Duda, Jessica M., Madarasmi, Saira, Rogers, Vaughn A., Yu, Esther, Pizzagalli, Diego A., Schroder, Hans S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984246/
https://www.ncbi.nlm.nih.gov/pubmed/36869258
http://dx.doi.org/10.3758/s13415-023-01073-9
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author Lamontagne, Steven J.
Duda, Jessica M.
Madarasmi, Saira
Rogers, Vaughn A.
Yu, Esther
Pizzagalli, Diego A.
Schroder, Hans S.
author_facet Lamontagne, Steven J.
Duda, Jessica M.
Madarasmi, Saira
Rogers, Vaughn A.
Yu, Esther
Pizzagalli, Diego A.
Schroder, Hans S.
author_sort Lamontagne, Steven J.
collection PubMed
description During the past 60 years, perceptions about the origins of mental illness have shifted toward a biomedical model, depicting depression as a biological disorder caused by genetic abnormalities and/or chemical imbalances. Despite benevolent intentions to reduce stigma, biogenetic messages promote prognostic pessimism, reduce feelings of agency, and alter treatment preferences, motivations, and expectations. However, no research has examined how these messages influence neural markers of ruminative activity or decision-making, a gap this study sought to fill. In this pre-registered, clinical trial (NCT03998748), 49 participants with current or past depressive experiences completed a sham saliva test and were randomly assigned to receive feedback that they either have (gene-present; n = 24) or do not have (gene-absent; n = 25) a genetic predisposition to depression. Before and after receiving the feedback, resting-state activity and neural correlates of cognitive control (error-related negativity [ERN] and error positivity [Pe]) were measured using high-density electroencephalogram (EEG). Participants also completed self-report measures of beliefs about the malleability and prognosis of depression and treatment motivation. Contrary to hypotheses, biogenetic feedback did not alter perceptions or beliefs about depression, nor did it alter EEG markers of self-directed rumination nor neurophysiological correlates of cognitive control. Explanations of these null findings are discussed in the context of prior studies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.3758/s13415-023-01073-9.
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spelling pubmed-99842462023-03-06 Limited impacts of biogenetic messaging on neural correlates of cognitive control and beliefs about depression Lamontagne, Steven J. Duda, Jessica M. Madarasmi, Saira Rogers, Vaughn A. Yu, Esther Pizzagalli, Diego A. Schroder, Hans S. Cogn Affect Behav Neurosci Research Article During the past 60 years, perceptions about the origins of mental illness have shifted toward a biomedical model, depicting depression as a biological disorder caused by genetic abnormalities and/or chemical imbalances. Despite benevolent intentions to reduce stigma, biogenetic messages promote prognostic pessimism, reduce feelings of agency, and alter treatment preferences, motivations, and expectations. However, no research has examined how these messages influence neural markers of ruminative activity or decision-making, a gap this study sought to fill. In this pre-registered, clinical trial (NCT03998748), 49 participants with current or past depressive experiences completed a sham saliva test and were randomly assigned to receive feedback that they either have (gene-present; n = 24) or do not have (gene-absent; n = 25) a genetic predisposition to depression. Before and after receiving the feedback, resting-state activity and neural correlates of cognitive control (error-related negativity [ERN] and error positivity [Pe]) were measured using high-density electroencephalogram (EEG). Participants also completed self-report measures of beliefs about the malleability and prognosis of depression and treatment motivation. Contrary to hypotheses, biogenetic feedback did not alter perceptions or beliefs about depression, nor did it alter EEG markers of self-directed rumination nor neurophysiological correlates of cognitive control. Explanations of these null findings are discussed in the context of prior studies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.3758/s13415-023-01073-9. Springer US 2023-03-03 2023 /pmc/articles/PMC9984246/ /pubmed/36869258 http://dx.doi.org/10.3758/s13415-023-01073-9 Text en © The Psychonomic Society, Inc. 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Article
Lamontagne, Steven J.
Duda, Jessica M.
Madarasmi, Saira
Rogers, Vaughn A.
Yu, Esther
Pizzagalli, Diego A.
Schroder, Hans S.
Limited impacts of biogenetic messaging on neural correlates of cognitive control and beliefs about depression
title Limited impacts of biogenetic messaging on neural correlates of cognitive control and beliefs about depression
title_full Limited impacts of biogenetic messaging on neural correlates of cognitive control and beliefs about depression
title_fullStr Limited impacts of biogenetic messaging on neural correlates of cognitive control and beliefs about depression
title_full_unstemmed Limited impacts of biogenetic messaging on neural correlates of cognitive control and beliefs about depression
title_short Limited impacts of biogenetic messaging on neural correlates of cognitive control and beliefs about depression
title_sort limited impacts of biogenetic messaging on neural correlates of cognitive control and beliefs about depression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984246/
https://www.ncbi.nlm.nih.gov/pubmed/36869258
http://dx.doi.org/10.3758/s13415-023-01073-9
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