Application of a genetic signature of late GU toxicity in SCIMITAR, a Post-op SBRT trial

Predictors of genitourinary toxicity after post-prostatectomy radiotherapy remain elusive. A previously defined germline DNA signature (PROSTOX) has shown predictive ability for late grade ≥ 2 GU toxicity after intact prostate stereotactic body radiotherapy. We explore whether PROSTOX would predict...

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Autores principales: Kishan, Amar U., Marco, Nicholas, Ma, Ting Martin, Steinberg, Michael L., Sachdeva, Ankush, Cao, Minsong, Ballas, Leslie K., Rietdorf, Emily, Telesca, Donatello, Weidhaas, Joanne B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984404/
https://www.ncbi.nlm.nih.gov/pubmed/36880064
http://dx.doi.org/10.1016/j.ctro.2023.100594
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author Kishan, Amar U.
Marco, Nicholas
Ma, Ting Martin
Steinberg, Michael L.
Sachdeva, Ankush
Cao, Minsong
Ballas, Leslie K.
Rietdorf, Emily
Telesca, Donatello
Weidhaas, Joanne B.
author_facet Kishan, Amar U.
Marco, Nicholas
Ma, Ting Martin
Steinberg, Michael L.
Sachdeva, Ankush
Cao, Minsong
Ballas, Leslie K.
Rietdorf, Emily
Telesca, Donatello
Weidhaas, Joanne B.
author_sort Kishan, Amar U.
collection PubMed
description Predictors of genitourinary toxicity after post-prostatectomy radiotherapy remain elusive. A previously defined germline DNA signature (PROSTOX) has shown predictive ability for late grade ≥ 2 GU toxicity after intact prostate stereotactic body radiotherapy. We explore whether PROSTOX would predict toxicity among patients receiving post-prostatectomy SBRT on a phase II clinical trial.
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spelling pubmed-99844042023-03-05 Application of a genetic signature of late GU toxicity in SCIMITAR, a Post-op SBRT trial Kishan, Amar U. Marco, Nicholas Ma, Ting Martin Steinberg, Michael L. Sachdeva, Ankush Cao, Minsong Ballas, Leslie K. Rietdorf, Emily Telesca, Donatello Weidhaas, Joanne B. Clin Transl Radiat Oncol Technical Note Predictors of genitourinary toxicity after post-prostatectomy radiotherapy remain elusive. A previously defined germline DNA signature (PROSTOX) has shown predictive ability for late grade ≥ 2 GU toxicity after intact prostate stereotactic body radiotherapy. We explore whether PROSTOX would predict toxicity among patients receiving post-prostatectomy SBRT on a phase II clinical trial. Elsevier 2023-02-08 /pmc/articles/PMC9984404/ /pubmed/36880064 http://dx.doi.org/10.1016/j.ctro.2023.100594 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Technical Note
Kishan, Amar U.
Marco, Nicholas
Ma, Ting Martin
Steinberg, Michael L.
Sachdeva, Ankush
Cao, Minsong
Ballas, Leslie K.
Rietdorf, Emily
Telesca, Donatello
Weidhaas, Joanne B.
Application of a genetic signature of late GU toxicity in SCIMITAR, a Post-op SBRT trial
title Application of a genetic signature of late GU toxicity in SCIMITAR, a Post-op SBRT trial
title_full Application of a genetic signature of late GU toxicity in SCIMITAR, a Post-op SBRT trial
title_fullStr Application of a genetic signature of late GU toxicity in SCIMITAR, a Post-op SBRT trial
title_full_unstemmed Application of a genetic signature of late GU toxicity in SCIMITAR, a Post-op SBRT trial
title_short Application of a genetic signature of late GU toxicity in SCIMITAR, a Post-op SBRT trial
title_sort application of a genetic signature of late gu toxicity in scimitar, a post-op sbrt trial
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984404/
https://www.ncbi.nlm.nih.gov/pubmed/36880064
http://dx.doi.org/10.1016/j.ctro.2023.100594
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