Ex-situ generation and synthetic utilization of bare trifluoromethyl anion in flow via rapid biphasic mixing

Fluoroform (CF(3)H) is the simplest reagent for nucleophilic trifluoromethylation intermediated by trifluoromethyl anion (CF(3)(–)). However, it has been well-known that CF(3)(–) should be generated in presence of a stabilizer or reaction partner (in-situ method) due to its short lifetime, which res...

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Detalles Bibliográficos
Autores principales: Lee, Hyune-Jea, Joo, Jeong-Un, Yim, Se-Jun, Kim, Dong-Pyo, Kim, Heejin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984407/
https://www.ncbi.nlm.nih.gov/pubmed/36869027
http://dx.doi.org/10.1038/s41467-022-35611-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984407/
https://www.ncbi.nlm.nih.gov/pubmed/36869027
http://dx.doi.org/10.1038/s41467-022-35611-9

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