mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion

Identifying the mechanisms underlying the regulation of immune checkpoint molecules and the therapeutic impact of targeting them in cancer is critical. Here we show that high expression of the immune checkpoint B7-H3 (CD276) and high mTORC1 activity correlate with immunosuppressive phenotypes and wo...

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Detalles Bibliográficos
Autores principales: Liu, Heng-Jia, Du, Heng, Khabibullin, Damir, Zarei, Mahsa, Wei, Kevin, Freeman, Gordon J., Kwiatkowski, David J., Henske, Elizabeth P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984496/
https://www.ncbi.nlm.nih.gov/pubmed/36869048
http://dx.doi.org/10.1038/s41467-023-36881-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984496/
https://www.ncbi.nlm.nih.gov/pubmed/36869048
http://dx.doi.org/10.1038/s41467-023-36881-7

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