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MARCH5 regulates mitotic apoptosis through MCL1-dependent and independent mechanisms
The anti-apoptotic MCL1 is critical for delaying apoptosis during mitotic arrest. MCL1 is degraded progressively during mitotic arrest, removing its anti-apoptotic function. We found that knockout of components of ubiquitin ligases including APC/C, SCF complexes, and the mitochondrial ubiquitin liga...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984497/ https://www.ncbi.nlm.nih.gov/pubmed/36329234 http://dx.doi.org/10.1038/s41418-022-01080-2 |