ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

Medulloblastoma, the most common malignant pediatric brain tumor, often harbors MYC amplifications. Compared to high-grade gliomas, MYC-amplified medulloblastomas often show increased photoreceptor activity and arise in the presence of a functional ARF/p53 suppressor pathway. Here, we generate an im...

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Detalles Bibliográficos
Autores principales: Mainwaring, Oliver J., Weishaupt, Holger, Zhao, Miao, Rosén, Gabriela, Borgenvik, Anna, Breinschmid, Laura, Verbaan, Annemieke D., Richardson, Stacey, Thompson, Dean, Clifford, Steven C., Hill, Rebecca M., Annusver, Karl, Sundström, Anders, Holmberg, Karl O., Kasper, Maria, Hutter, Sonja, Swartling, Fredrik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984535/
https://www.ncbi.nlm.nih.gov/pubmed/36869047
http://dx.doi.org/10.1038/s41467-023-36847-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984535/
https://www.ncbi.nlm.nih.gov/pubmed/36869047
http://dx.doi.org/10.1038/s41467-023-36847-9

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