Polynucleotide phosphorylase protects against renal tubular injury via blocking mt-dsRNA-PKR-eIF2α axis

Renal tubular atrophy is a hallmark of chronic kidney disease. The cause of tubular atrophy, however, remains elusive. Here we report that reduction of renal tubular cell polynucleotide phosphorylase (PNPT1) causes renal tubular translation arrest and atrophy. Analysis of tubular atrophic tissues fr...

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Detalles Bibliográficos
Autores principales: Zhu, Yujie, Zhang, Mingchao, Wang, Weiran, Qu, Shuang, Liu, Minghui, Rong, Weiwei, Yang, Wenwen, Liang, Hongwei, Zeng, Caihong, Zhu, Xiaodong, Li, Limin, Liu, Zhihong, Zen, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984537/
https://www.ncbi.nlm.nih.gov/pubmed/36869030
http://dx.doi.org/10.1038/s41467-023-36664-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984537/
https://www.ncbi.nlm.nih.gov/pubmed/36869030
http://dx.doi.org/10.1038/s41467-023-36664-0

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