Cargando…
Moesin is an effector of tau-induced actin overstabilization, cell cycle activation, and neurotoxicity in Alzheimer’s disease
In Alzheimer’s disease, neurons acquire phenotypes that are also present in various cancers, including aberrant activation of the cell cycle. Unlike cancer, cell cycle activation in post-mitotic neurons is sufficient to induce cell death. Multiple lines of evidence suggest that abortive cell cycle a...
Autores principales: | Beckmann, Adrian, Ramirez, Paulino, Gamez, Maria, Gonzalez, Elias, De Mange, Jasmine, Bieniek, Kevin F., Ray, William J., Frost, Bess |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984563/ https://www.ncbi.nlm.nih.gov/pubmed/36879821 http://dx.doi.org/10.1016/j.isci.2023.106152 |
Ejemplares similares
-
Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation
por: Ochoa, Elizabeth, et al.
Publicado: (2023) -
PATHOLOGICAL TAU ABORTS CELL CYCLE ACTIVATION BY MIMICKING EPITHELIAL-MESENCHYMAL-TRANSITION IN NEURONS
por: Phan, Roseann V, et al.
Publicado: (2019) -
Pathogenic Tau Causes a Toxic Depletion of Nuclear
Calcium
por: Mahoney, Rebekah, et al.
Publicado: (2020) -
Moesin and cortactin control actin-dependent multivesicular endosome biogenesis
por: Muriel, Olivia, et al.
Publicado: (2016) -
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics
por: Bardai, Farah H., et al.
Publicado: (2018)