In silico identification of A1 agonists and A2a inhibitors in pain based on molecular docking strategies and dynamics simulations

Most recently, the adenosine is considered as one of the most promising targets for treating pain, with few side effects. It exists in the central nervous system, and plays a key role in nociceptive afferent pathway. It is reported that the A1 receptor (A1R) could inhibit Ca(2+) channels to reduce t...

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Detalles Bibliográficos
Autores principales: Xu, Guangya, Zhang, Shutao, Zheng, Lulu, Hu, Zhongjiao, Cheng, Lijia, Chen, Lvlin, Li, Jun, Shi, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984648/
https://www.ncbi.nlm.nih.gov/pubmed/34677752
http://dx.doi.org/10.1007/s11302-021-09808-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984648/
https://www.ncbi.nlm.nih.gov/pubmed/34677752
http://dx.doi.org/10.1007/s11302-021-09808-4

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