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In silico identification of A1 agonists and A2a inhibitors in pain based on molecular docking strategies and dynamics simulations
Most recently, the adenosine is considered as one of the most promising targets for treating pain, with few side effects. It exists in the central nervous system, and plays a key role in nociceptive afferent pathway. It is reported that the A1 receptor (A1R) could inhibit Ca(2+) channels to reduce t...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Netherlands
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984648/ https://www.ncbi.nlm.nih.gov/pubmed/34677752 http://dx.doi.org/10.1007/s11302-021-09808-4 |