Machine learning reveals STAT motifs as predictors for GR-mediated gene repression

Glucocorticoids are potent immunosuppressive drugs, but long-term treatment leads to severe side-effects. While there is a commonly accepted model for GR-mediated gene activation, the mechanism behind repression remains elusive. Understanding the molecular action of the glucocorticoid receptor (GR)...

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Detalles Bibliográficos
Autores principales: Höllbacher, Barbara, Strickland, Benjamin, Greulich, Franziska, Uhlenhaut, N. Henriette, Heinig, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984779/
https://www.ncbi.nlm.nih.gov/pubmed/36879886
http://dx.doi.org/10.1016/j.csbj.2023.02.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984779/
https://www.ncbi.nlm.nih.gov/pubmed/36879886
http://dx.doi.org/10.1016/j.csbj.2023.02.015

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