Specific reprogramming of alpha cells to insulin-producing cells by short glucagon promoter-driven Pdx1 and MafA

Endogenous reprogramming of pancreas-derived non-beta cells into insulin-producing cells is a promising approach to treat type 1 diabetes (T1D). One strategy that has yet to be explored is the specific delivery of insulin-producing essential genes, Pdx1 and MafA, to pancreatic alpha cells to reprogr...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Ping, Zhang, Ting, Lu, Aiping, Shiota, Chiyo, Huard, Matthieu, Whitney, Kaitlyn E., Huard, Johnny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984919/
https://www.ncbi.nlm.nih.gov/pubmed/36879848
http://dx.doi.org/10.1016/j.omtm.2023.02.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984919/
https://www.ncbi.nlm.nih.gov/pubmed/36879848
http://dx.doi.org/10.1016/j.omtm.2023.02.003

Ejemplares similares