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Recent advancements in the structural biology of human telomerase and their implications for improved design of cancer therapeutics
Telomerase is a specialized reverse transcriptase that synthesizes telomeric repeats at the ends of linear chromosomes. Telomerase is transiently expressed in germ and stem cells, but nearly all somatic cells silence it after differentiating. However, the vast majority of cancer cells reactivate and...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984990/ https://www.ncbi.nlm.nih.gov/pubmed/36879683 http://dx.doi.org/10.1093/narcan/zcad010 |