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A one-step gram-scale protocol for stereoselective domino dimerization to asperazine A analogs

Here, we present an efficient protocol for stereoselective 4N-based domino dimerization in one single step, establishing a 22-membered library of asperazine A analogs. We describe steps for performing a gram-scale 2N-monomer to access the unsymmetrical 4N-dimer. We detail the synthesis of the desire...

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Detalles Bibliográficos
Autores principales: Bai, Leiyang, Fu, Bei, Jiang, Xuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985029/
https://www.ncbi.nlm.nih.gov/pubmed/36861828
http://dx.doi.org/10.1016/j.xpro.2023.102114