New IMB16-4 Hot-Melt Extrusion Preparation Improved Oral Bioavailability and Enhanced Anti-Cholestatic Effect on Rats

BACKGROUND: Cholestasis is challenging to treat due to lacked effective drugs. N-(3,4,5-trichlorophenyl)-2 (3-nitrobenzenesulfonamido) benzamide, abbreviated as IMB16-4, which may be effective for the treatment of cholestasis. However, its poor solubility and bioavailability seriously obstruct the r...

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Detalles Bibliográficos
Autores principales: Li, Yuqin, Tian, Changlin, Song, Xiaofei, Du, Mengying, Zhang, Guoning, Liu, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985389/
https://www.ncbi.nlm.nih.gov/pubmed/36879928
http://dx.doi.org/10.2147/DDDT.S395114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985389/
https://www.ncbi.nlm.nih.gov/pubmed/36879928
http://dx.doi.org/10.2147/DDDT.S395114

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