Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage

The Thyroid Hormone (TH) activating enzyme, type 2 Deiodinase (D2), is functionally required to elevate the TH concentration during cancer progression to advanced stages. However, the mechanisms regulating D2 expression in cancer still remain poorly understood. Here, we show that the cell stress sen...

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Detalles Bibliográficos
Autores principales: Nappi, Annarita, Miro, Caterina, Pezone, Antonio, Tramontano, Alfonso, Di Cicco, Emery, Sagliocchi, Serena, Cicatiello, Annunziata Gaetana, Murolo, Melania, Torabinejad, Sepehr, Abbotto, Elena, Caiazzo, Giuseppina, Raia, Maddalena, Stornaiuolo, Mariano, Antonini, Dario, Fabbrocini, Gabriella, Salvatore, Domenico, Avvedimento, Vittorio Enrico, Dentice, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985592/
https://www.ncbi.nlm.nih.gov/pubmed/36871014
http://dx.doi.org/10.1038/s41467-023-36755-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985592/
https://www.ncbi.nlm.nih.gov/pubmed/36871014
http://dx.doi.org/10.1038/s41467-023-36755-y

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