Structural basis of HIV-1 maturation inhibitor binding and activity

HIV-1 maturation inhibitors (MIs), Bevirimat (BVM) and its analogs interfere with the catalytic cleavage of spacer peptide 1 (SP1) from the capsid protein C-terminal domain (CA(CTD)), by binding to and stabilizing the CA(CTD)-SP1 region. MIs are under development as alternative drugs to augment curr...

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Detalles Bibliográficos
Autores principales: Sarkar, Sucharita, Zadrozny, Kaneil K., Zadorozhnyi, Roman, Russell, Ryan W., Quinn, Caitlin M., Kleinpeter, Alex, Ablan, Sherimay, Meshkin, Hamed, Perilla, Juan R., Freed, Eric O., Ganser-Pornillos, Barbie K., Pornillos, Owen, Gronenborn, Angela M., Polenova, Tatyana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985623/
https://www.ncbi.nlm.nih.gov/pubmed/36871077
http://dx.doi.org/10.1038/s41467-023-36569-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985623/
https://www.ncbi.nlm.nih.gov/pubmed/36871077
http://dx.doi.org/10.1038/s41467-023-36569-y

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