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Discovery of novel DNA‐damaging agents through phenotypic screening for DNA double‐strand break

DNA double‐strand breaks (DSBs) seriously damage DNA and promote genomic instability that can lead to cell death. They are the source of conditions such as carcinogenesis and aging, but also have important applications in cancer therapy. Therefore, rapid detection and quantification of DSBs in cells...

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Detalles Bibliográficos
Autores principales: Zhang, Doudou, Shimokawa, Takashi, Guo, Qianqian, Dan, Shingo, Miki, Yoshio, Sunada, Shigeaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986057/
https://www.ncbi.nlm.nih.gov/pubmed/36385507
http://dx.doi.org/10.1111/cas.15659