Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain

The Omicron variant of SARS-CoV-2 is not effectively neutralized by most antibodies elicited by two doses of mRNA vaccines, but a third dose increases anti-Omicron neutralizing antibodies. We reveal mechanisms underlying this observation by combining computational modeling with data from vaccinated...

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Detalles Bibliográficos
Autores principales: Yang, Leerang, Van Beek, Matthew, Wang, Zijun, Muecksch, Frauke, Canis, Marie, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C., Chakraborty, Arup K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986127/
https://www.ncbi.nlm.nih.gov/pubmed/36952347
http://dx.doi.org/10.1016/j.celrep.2023.112256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986127/
https://www.ncbi.nlm.nih.gov/pubmed/36952347
http://dx.doi.org/10.1016/j.celrep.2023.112256

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