Cryo-electron microscopy structures of human thyroid peroxidase (TPO) in complex with TPO antibodies

Determination of the structure of the extracellular domain of human thyroid peroxidase (hTPO) by cryo-electron microscopy (cryo-EM) is described. TPO, purified to homogeneity was complexed with the hTPO monoclonal autoantibody 2G4 Fab and also with a mouse monoclonal TPO antibody 4F5 Fab (which comp...

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Detalles Bibliográficos
Autores principales: Baker, Stuart, Miguel, Ricardo Núñez, Thomas, Daniel, Powell, Michael, Furmaniak, Jadwiga, Smith, Bernard Rees
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986399/
https://www.ncbi.nlm.nih.gov/pubmed/36537574
http://dx.doi.org/10.1530/JME-22-0149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986399/
https://www.ncbi.nlm.nih.gov/pubmed/36537574
http://dx.doi.org/10.1530/JME-22-0149

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