Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data

A physiologically based pharmacokinetic model for di-(2-ethylhexyl) terephthalate (DEHTP) based on a refined model for di-(2-propylheptyl) phthalate (DPHP) was developed to interpret the metabolism and biokinetics of DEHTP following a single oral dose of 50 mg to three male volunteers. In vitro and...

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Detalles Bibliográficos
Autores principales: McNally, Kevin, Sams, Craig, Hogg, Alex, Loizou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986446/
https://www.ncbi.nlm.nih.gov/pubmed/36891271
http://dx.doi.org/10.3389/fphar.2023.1140852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986446/
https://www.ncbi.nlm.nih.gov/pubmed/36891271
http://dx.doi.org/10.3389/fphar.2023.1140852

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