T-CAST: An optimized CAST-Seq pipeline for TALEN confirms superior safety and efficacy of obligate-heterodimeric scaffolds

Transcription activator-like effector nucleases (TALENs) are programmable nucleases that have entered the clinical stage. Each subunit of the dimer consists of a DNA-binding domain composed of an array of TALE repeats fused to the catalytically active portion of the FokI endonuclease. Upon DNA-bindi...

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Detalles Bibliográficos
Autores principales: Rhiel, Manuel, Geiger, Kerstin, Andrieux, Geoffroy, Rositzka, Julia, Boerries, Melanie, Cathomen, Toni, Cornu, Tatjana I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genome Editing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986454/
https://www.ncbi.nlm.nih.gov/pubmed/36890979
http://dx.doi.org/10.3389/fgeed.2023.1130736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986454/
https://www.ncbi.nlm.nih.gov/pubmed/36890979
http://dx.doi.org/10.3389/fgeed.2023.1130736

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