Dapagliflozin alleviates myocardial ischemia/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition

Reperfusion is essential for ischemic myocardium but paradoxically leads to myocardial damage that worsens cardiac functions. Ferroptosis often occurs in cardiomyocytes during ischemia/reperfusion (I/R). The SGLT2 inhibitor dapagliflozin (DAPA) exerts cardioprotective effects independent of hypoglyc...

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Detalles Bibliográficos
Autores principales: Chen, Weixiang, Zhang, Yue, Wang, Zuoxiang, Tan, Mingyue, Lin, Jia, Qian, Xiaodong, Li, Hongxia, Jiang, Tingbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986553/
https://www.ncbi.nlm.nih.gov/pubmed/36891270
http://dx.doi.org/10.3389/fphar.2023.1078205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986553/
https://www.ncbi.nlm.nih.gov/pubmed/36891270
http://dx.doi.org/10.3389/fphar.2023.1078205

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