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Simulation of dosimetric consequences of intrafraction variation of tumor drift in lung cancer stereotactic body radiotherapy

OBJECTIVE: The purpose of this study was to investigate the target dose discrepancy caused by intrafraction variation during stereotactic body radiotherapy (SBRT) for lung cancer. METHODS: Intensity-modulated radiation therapy (IMRT) plans were designed based on average computed tomography (AVG CT)...

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Autores principales: Han, Bin, Wu, Bian, Hu, Fala, Ma, Yangguang, Wang, Haiyang, Han, Xinwei, Liu, Gang, Guo, Yuexin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987420/
https://www.ncbi.nlm.nih.gov/pubmed/36891502
http://dx.doi.org/10.3389/fonc.2022.1010411
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author Han, Bin
Wu, Bian
Hu, Fala
Ma, Yangguang
Wang, Haiyang
Han, Xinwei
Liu, Gang
Guo, Yuexin
author_facet Han, Bin
Wu, Bian
Hu, Fala
Ma, Yangguang
Wang, Haiyang
Han, Xinwei
Liu, Gang
Guo, Yuexin
author_sort Han, Bin
collection PubMed
description OBJECTIVE: The purpose of this study was to investigate the target dose discrepancy caused by intrafraction variation during stereotactic body radiotherapy (SBRT) for lung cancer. METHODS: Intensity-modulated radiation therapy (IMRT) plans were designed based on average computed tomography (AVG CT) utilizing the planning target volume (PTV) surrounding the 65% and 85% prescription isodoses in both phantom and patient cases. Variation was simulated by shifting the nominal plan isocenter along six directions from 0.5 mm to 4.5 mm with a 1-mm step size to produce a series of perturbed plans. The dose discrepancy between the initial plan and the perturbed plans was calculated as the percentage of the initial plan. Dose indices, including ΔD(99) for internal target volume (ITV) and gross tumor volume (GTV), were adopted as endpoint samples. The mean dose discrepancy was calculated under the 3-dimensional space distribution. RESULTS: We found that motion can lead to serious dose degradation of the target and ITV in lung SBRT, especially during SBRT with PTV surrounding the lower isodose line. Lower isodose line may lead to larger dose discrepancy, while make steeper dose fall-off gradient. This phenomenon was compromised when 3-dimensional space distribution was considered. DISCUSSION: This result may provide a prospective reference for target dose degradation due to motion during lung SBRT treatment.
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spelling pubmed-99874202023-03-07 Simulation of dosimetric consequences of intrafraction variation of tumor drift in lung cancer stereotactic body radiotherapy Han, Bin Wu, Bian Hu, Fala Ma, Yangguang Wang, Haiyang Han, Xinwei Liu, Gang Guo, Yuexin Front Oncol Oncology OBJECTIVE: The purpose of this study was to investigate the target dose discrepancy caused by intrafraction variation during stereotactic body radiotherapy (SBRT) for lung cancer. METHODS: Intensity-modulated radiation therapy (IMRT) plans were designed based on average computed tomography (AVG CT) utilizing the planning target volume (PTV) surrounding the 65% and 85% prescription isodoses in both phantom and patient cases. Variation was simulated by shifting the nominal plan isocenter along six directions from 0.5 mm to 4.5 mm with a 1-mm step size to produce a series of perturbed plans. The dose discrepancy between the initial plan and the perturbed plans was calculated as the percentage of the initial plan. Dose indices, including ΔD(99) for internal target volume (ITV) and gross tumor volume (GTV), were adopted as endpoint samples. The mean dose discrepancy was calculated under the 3-dimensional space distribution. RESULTS: We found that motion can lead to serious dose degradation of the target and ITV in lung SBRT, especially during SBRT with PTV surrounding the lower isodose line. Lower isodose line may lead to larger dose discrepancy, while make steeper dose fall-off gradient. This phenomenon was compromised when 3-dimensional space distribution was considered. DISCUSSION: This result may provide a prospective reference for target dose degradation due to motion during lung SBRT treatment. Frontiers Media S.A. 2022-12-08 /pmc/articles/PMC9987420/ /pubmed/36891502 http://dx.doi.org/10.3389/fonc.2022.1010411 Text en Copyright © 2022 Han, Wu, Hu, Ma, Wang, Han, Liu and Guo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Han, Bin
Wu, Bian
Hu, Fala
Ma, Yangguang
Wang, Haiyang
Han, Xinwei
Liu, Gang
Guo, Yuexin
Simulation of dosimetric consequences of intrafraction variation of tumor drift in lung cancer stereotactic body radiotherapy
title Simulation of dosimetric consequences of intrafraction variation of tumor drift in lung cancer stereotactic body radiotherapy
title_full Simulation of dosimetric consequences of intrafraction variation of tumor drift in lung cancer stereotactic body radiotherapy
title_fullStr Simulation of dosimetric consequences of intrafraction variation of tumor drift in lung cancer stereotactic body radiotherapy
title_full_unstemmed Simulation of dosimetric consequences of intrafraction variation of tumor drift in lung cancer stereotactic body radiotherapy
title_short Simulation of dosimetric consequences of intrafraction variation of tumor drift in lung cancer stereotactic body radiotherapy
title_sort simulation of dosimetric consequences of intrafraction variation of tumor drift in lung cancer stereotactic body radiotherapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987420/
https://www.ncbi.nlm.nih.gov/pubmed/36891502
http://dx.doi.org/10.3389/fonc.2022.1010411
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