Mitochondrial DNA in cell death and inflammation

Cytosolic DNA is recognized by the innate immune system as a potential threat. During apoptotic cell death, mitochondrial DNA (mtDNA) release activates the DNA sensor cyclic GMP–AMP synthase (cGAS) to promote a pro-inflammatory type I interferon response. Inflammation following mtDNA release during...

Descripción completa

Detalles Bibliográficos
Autores principales: Heilig, Rosalie, Lee, Jordan, Tait, Stephen W.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988000/
https://www.ncbi.nlm.nih.gov/pubmed/36815695
http://dx.doi.org/10.1042/BST20221525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988000/
https://www.ncbi.nlm.nih.gov/pubmed/36815695
http://dx.doi.org/10.1042/BST20221525

Ejemplares similares