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Mitochondrial DNA in cell death and inflammation

Cytosolic DNA is recognized by the innate immune system as a potential threat. During apoptotic cell death, mitochondrial DNA (mtDNA) release activates the DNA sensor cyclic GMP–AMP synthase (cGAS) to promote a pro-inflammatory type I interferon response. Inflammation following mtDNA release during...

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Detalles Bibliográficos
Autores principales:	Heilig, Rosalie, Lee, Jordan, Tait, Stephen W.G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2023
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988000/ https://www.ncbi.nlm.nih.gov/pubmed/36815695 http://dx.doi.org/10.1042/BST20221525

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