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Ubiquitination of NKCC2 by the cullin-RING E3 ubiquitin ligase family in the thick ascending limb of the loop of Henle
The Na(+)/K(+)/2Cl(−) cotransporter (NKCC2) in the thick ascending limb of the loop of Henle (TAL) mediates NaCl reabsorption. cGMP, the second messenger of nitric oxide and atrial natriuretic peptide, inhibits NKCC2 activity by stimulating NKCC2 ubiquitination and decreasing surface NKCC2 levels. A...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Physiological Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988521/ https://www.ncbi.nlm.nih.gov/pubmed/36727946 http://dx.doi.org/10.1152/ajprenal.00079.2022 |