Deficiency of Perry syndrome-associated p150(Glued) in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities

Multiple missense mutations in p150(Glued) are linked to Perry syndrome (PS), a rare neurodegenerative disease pathologically characterized by loss of nigral dopaminergic (DAergic) neurons. Here we generated p150(Glued) conditional knockout (cKO) mice by deleting p150(Glued) in midbrain DAergic neur...

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Detalles Bibliográficos
Autores principales: Yu, Jia, Yang, Xuan, Zheng, Jiayin, Sgobio, Carmelo, Sun, Lixin, Cai, Huaibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988887/
https://www.ncbi.nlm.nih.gov/pubmed/36879021
http://dx.doi.org/10.1038/s41531-023-00478-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988887/
https://www.ncbi.nlm.nih.gov/pubmed/36879021
http://dx.doi.org/10.1038/s41531-023-00478-0

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