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Deficiency of Perry syndrome-associated p150(Glued) in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities
Multiple missense mutations in p150(Glued) are linked to Perry syndrome (PS), a rare neurodegenerative disease pathologically characterized by loss of nigral dopaminergic (DAergic) neurons. Here we generated p150(Glued) conditional knockout (cKO) mice by deleting p150(Glued) in midbrain DAergic neur...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988887/ https://www.ncbi.nlm.nih.gov/pubmed/36879021 http://dx.doi.org/10.1038/s41531-023-00478-0 |