Cargando…

Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression

Metabolic reprogramming is a hallmark of cancer. However, it is not well known how metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA oxidase 1 (ACOX1) suppresses colorectal cancer (CRC) progression by regulating palmitic acid (PA) reprogramming. ACOX1 is highly down...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Qiang, Yang, Xiaoya, Wu, Jinjie, Ye, Shubiao, Gong, Junli, Cheng, Wai Ming, Luo, Zhanhao, Yu, Jing, Liu, Yugeng, Zeng, Wanyi, Liu, Chen, Xiong, Zhizhong, Chen, Yuan, He, Zhen, Lan, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Nature Singapore 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9988979/ https://www.ncbi.nlm.nih.gov/pubmed/36878899 http://dx.doi.org/10.1038/s41421-022-00515-x

Ejemplares similares

Author Correction: Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression
por: Zhang, Qiang, et al.
Publicado: (2023)

Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis
por: Kong, Yue, et al.
Publicado: (2023)

c‐Myc–IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming
por: Zhang, Qiang, et al.
Publicado: (2023)

Targeting protein palmitoylation decreases palmitate-induced sphere formation of human liver cancer cells
por: Chong, Lee-Won, et al.
Publicado: (2020)

Altered expression of ACOX2 in non-small cell lung cancer
por: Sui, Jane S. Y., et al.
Publicado: (2022)

Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice
por: Zhang, Yuan, et al.
Publicado: (2022)

Protein palmitoylation-mediated palmitic acid sensing causes blood-testis barrier damage via inducing ER stress
por: Ge, Xie, et al.
Publicado: (2022)

ACOX-driven peroxisomal heterogeneity and functional compartmentalization in brown adipocytes of hypothyroid rats
por: Aleksic, Marija, et al.
Publicado: (2023)

Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation
por: You, Lei, et al.
Publicado: (2020)

Loss of ACOX1 in clear cell renal cell carcinoma and its correlation with clinical features
por: Mo, Yingxi, et al.
Publicado: (2023)

ACOX1, regulated by C/EBPα and miR-25-3p, promotes bovine preadipocyte adipogenesis
por: Zhang, Feng, et al.
Publicado: (2021)

Variability of ACOX1 Gene Polymorphisms across Different Horse Breeds with Regard to Selection Pressure
por: Myćka, Grzegorz, et al.
Publicado: (2020)

Palmitoylation of δ-catenin by DHHC5 Mediates Activity-Induced Synapse Plasticity
por: Brigidi, G. Stefano, et al.
Publicado: (2014)

ACOX1 destabilizes p73 to suppress intrinsic apoptosis pathway and regulates sensitivity to doxorubicin in lymphoma cells
por: Zheng, Fei-Meng, et al.
Publicado: (2019)

EYA4 inhibits hepatocellular carcinoma by repressing MYCBP by dephosphorylating β‐catenin at Ser552
por: Zhu, Xiao‐Xu, et al.
Publicado: (2019)

ACOX2 is a prognostic marker and impedes the progression of hepatocellular carcinoma via PPARα pathway
por: Zhang, Qifan, et al.
Publicado: (2021)

Protein Lipidation by Palmitoylation and Myristoylation in Cancer
por: Fhu, Chee Wai, et al.
Publicado: (2021)

Dietary iron modulates gut microbiota and induces SLPI secretion to promote colorectal tumorigenesis
por: Liu, Chen, et al.
Publicado: (2023)

Mesenteric Adipose Tissue‐Derived Klebsiella variicola Disrupts Intestinal Barrier and Promotes Colitis by Type VI Secretion System
por: Gong, Junli, et al.
Publicado: (2023)

A de novo heterozygous variant in ACOX1 gene cause Mitchell syndrome: the first case in China and literature review
por: Shen, Mengxiao, et al.
Publicado: (2023)

LncRNA TGFB2-OT1 Promotes Progression and Angiogenesis in Hepatocellular Carcinoma by Dephosphorylating β-Catenin
por: Chen, Yiran, et al.
Publicado: (2023)

Neural Palmitoyl-Proteomics Reveals Dynamic Synaptic Palmitoylation
por: Kang, Rujun, et al.
Publicado: (2008)

Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus
por: Lieu, Calvin V., et al.
Publicado: (2021)

Protein Palmitoylation Modification During Viral Infection and Detection Methods of Palmitoylated Proteins
por: Li, Xiaoling, et al.
Publicado: (2022)

MicroRNA-15a Regulates the Differentiation of Intramuscular Preadipocytes by Targeting ACAA1, ACOX1 and SCP2 in Chickens
por: Li, Guoxi, et al.
Publicado: (2019)

Learning by palmitoylation
por: LeBrasseur, Nicole
Publicado: (2002)

Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
por: Holder, James, et al.
Publicado: (2020)

MiR-31-5p-ACOX1 Axis Enhances Tumorigenic Fitness in Oral Squamous Cell Carcinoma Via the Promigratory Prostaglandin E2
por: Lai, Yi-Hsuan, et al.
Publicado: (2018)

Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas
por: Bjørklund, Sunniva Stordal, et al.
Publicado: (2015)

Beneficial effect of ursodeoxycholic acid in patients with acyl‐CoA oxidase 2 (ACOX2) deficiency–associated hypertransaminasemia
por: Alonso‐Peña, Marta, et al.
Publicado: (2022)

Acyl-CoA oxidase ACOX-1 interacts with a peroxin PEX-5 to play roles in larval development of Haemonchus contortus
por: Shi, Hengzhi, et al.
Publicado: (2021)

Combined effects of FH (E404D) and ACOX2 (R409H) cause metabolic defects in primary cardiac malignant tumor
por: Zhou, Xiangyu, et al.
Publicado: (2018)

The Associations of PMF1, ICAM1, AGT, TRIM65, FBF1, and ACOX1 Variants With Leukoaraiosis in Chinese Population
por: Huang, Wen-Qing, et al.
Publicado: (2019)

MiR-103-3p promotes hepatic steatosis to aggravate nonalcoholic fatty liver disease by targeting of ACOX1
por: Ding, Jiexia, et al.
Publicado: (2022)

Microbiota in mesenteric adipose tissue from Crohn’s disease promote colitis in mice
por: He, Zhen, et al.
Publicado: (2021)

Protein S-palmitoylation in immunity
por: Das, Tandrila, et al.
Publicado: (2021)

Arrestin Facilitates Rhodopsin Dephosphorylation in Vivo
por: Hsieh, Chia-Ling, et al.
Publicado: (2022)

Palmitic Acid-Induced Neuron Cell Cycle G(2)/M Arrest and Endoplasmic Reticular Stress through Protein Palmitoylation in SH-SY5Y Human Neuroblastoma Cells
por: Hsiao, Yung-Hsuan, et al.
Publicado: (2014)

ENZYMATIC DEPHOSPHORYLATION OF OVALBUMIN AND PLAKALBUMIN
por: Perlmann, Gertrude E.
Publicado: (1952)

ENZYMIC DEPHOSPHORYLATION OF PEPSIN AND PEPSINOGEN
por: Perlmann, Gertrude E.
Publicado: (1958)

Cannot write session to /tmp/vufind_sessions/sess_r9o2n17v97tju24e9q7njebq2g