Integration of bulk RNA sequencing and single-cell analysis reveals a global landscape of DNA damage response in the immune environment of Alzheimer’s disease

BACKGROUND: We developed a novel system for quantifying DNA damage response (DDR) to help diagnose and predict the risk of Alzheimer’s disease (AD). METHODS: We thoroughly estimated the DDR patterns in AD patients Using 179 DDR regulators. Single-cell techniques were conducted to validate the DDR le...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Yongxing, Lin, Han, Chen, Manli, Lin, Xin, Wu, Lijuan, Zhao, Yinan, Lin, Fan, Lin, Chunjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989175/
https://www.ncbi.nlm.nih.gov/pubmed/36895559
http://dx.doi.org/10.3389/fimmu.2023.1115202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989175/
https://www.ncbi.nlm.nih.gov/pubmed/36895559
http://dx.doi.org/10.3389/fimmu.2023.1115202

Ejemplares similares