Pharmacophore-Aided Virtual Screening and Molecular Dynamics Simulation Identifies TrkB Agonists for Treatment of CDKL5-Deficiency Disorders

Therapeutic intervention in cyclin-dependent kinase-like 5 (CDKL5) deficiency disorders (CDDs) has remained a concern over the years. Recent advances into the mechanistic interplay of signalling pathways has revealed the role of deficient tropomyosin receptor kinase B (TrkB)/phospholipase C γ1 signa...

Descripción completa

Detalles Bibliográficos
Autores principales: Ademuwagun, Ibitayo Abigail, Oduselu, Gbolahan Oladipupo, Rotimi, Solomon Oladapo, Adebiyi, Ezekiel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989394/
https://www.ncbi.nlm.nih.gov/pubmed/36895324
http://dx.doi.org/10.1177/11779322231158254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989394/
https://www.ncbi.nlm.nih.gov/pubmed/36895324
http://dx.doi.org/10.1177/11779322231158254

Ejemplares similares