Cargando…

Pharmacophore-Aided Virtual Screening and Molecular Dynamics Simulation Identifies TrkB Agonists for Treatment of CDKL5-Deficiency Disorders

Therapeutic intervention in cyclin-dependent kinase-like 5 (CDKL5) deficiency disorders (CDDs) has remained a concern over the years. Recent advances into the mechanistic interplay of signalling pathways has revealed the role of deficient tropomyosin receptor kinase B (TrkB)/phospholipase C γ1 signa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ademuwagun, Ibitayo Abigail, Oduselu, Gbolahan Oladipupo, Rotimi, Solomon Oladapo, Adebiyi, Ezekiel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2023
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989394/ https://www.ncbi.nlm.nih.gov/pubmed/36895324 http://dx.doi.org/10.1177/11779322231158254

Ejemplares similares

Structure-based pharmacophore modeling, virtual screening, and molecular dynamics simulation studies for identification of Plasmodium falciparum 5-aminolevulinate synthase inhibitors
por: Oduselu, Gbolahan O., et al.
Publicado: (2023)

Voltage Gated Sodium Channel Genes in Epilepsy: Mutations, Functional Studies, and Treatment Dimensions
por: Ademuwagun, Ibitayo Abigail, et al.
Publicado: (2021)

Recent advances in functionalized quinoline scaffolds and hybrids—Exceptional pharmacophore in therapeutic medicine
por: Elebiju, Oluwadunni F., et al.
Publicado: (2023)

Functional and Structural Impairments in the Perirhinal Cortex of a Mouse Model of CDKL5 Deficiency Disorder Are Rescued by a TrkB Agonist
por: Ren, Elisa, et al.
Publicado: (2019)

Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists
por: Pankiewicz, Piotr, et al.
Publicado: (2021)

Therapeutic potential of a TrkB agonistic antibody for Alzheimer's disease
por: Wang, Shudan, et al.
Publicado: (2020)

Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage
por: Wu, Chun-Hu, et al.
Publicado: (2019)

The TrkB agonist, 7,8-dihydroxyflavone, impairs fracture healing in mice
por: Johnstone, Maddison R., et al.
Publicado: (2021)

Homology Modelling and Molecular Docking Studies of Selected Substituted Benzo[d]imidazol-1-yl)methyl)benzimidamide Scaffolds on Plasmodium falciparum Adenylosuccinate Lyase Receptor
por: Oduselu, Gbolahan O, et al.
Publicado: (2019)

Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity
por: Vidaurre, Ó G, et al.
Publicado: (2012)

Anopheles gambiae Trehalase Inhibitors for Malaria Vector Control: A Molecular Docking and Molecular Dynamics Study
por: Adedeji, Eunice O., et al.
Publicado: (2022)

Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates
por: Lin, John C., et al.
Publicado: (2008)

A Monoclonal Antibody TrkB Receptor Agonist as a Potential Therapeutic for Huntington’s Disease
por: Todd, Daniel, et al.
Publicado: (2014)

Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction
por: Greising, Sarah M., et al.
Publicado: (2017)

TrkB-Targeted Therapy for Mucoepidermoid Carcinoma
por: Wagner, Vivian P., et al.
Publicado: (2020)

Actions of the TrkB Agonist Antibody ZEB85 in Regulating the Architecture and Synaptic Plasticity in Hippocampal Neurons
por: Tacke, Charlotte, et al.
Publicado: (2022)

Taste Neurons Consist of Both a Large TrkB-Receptor-Dependent and a Small TrkB-Receptor-Independent Subpopulation
por: Fei, Da, et al.
Publicado: (2013)

Synthesis, in silico and in vitro antimicrobial efficacy of substituted arylidene-based quinazolin-4(3H)-one motifs
por: Oduselu, Gbolahan O., et al.
Publicado: (2023)

The Role of BDNF-TrkB Signaling in the Pathogenesis of PTSD
por: Green, Christopher R., et al.
Publicado: (2013)

Bidirectional coordination of actions and habits by TrkB in mice
por: Pitts, Elizabeth G., et al.
Publicado: (2018)

Cholinergic neuroplasticity in asthma driven by TrkB signaling
por: Dragunas, Guilherme, et al.
Publicado: (2020)

Legumain Functions as a Transient TrkB Sheddase
por: Holzner, Christoph, et al.
Publicado: (2023)

Linking Hypothermia and Altered Metabolism with TrkB Activation
por: Alitalo, Okko, et al.
Publicado: (2023)

A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin
por: Xiong, Jing, et al.
Publicado: (2022)

Selective activation and down‐regulation of Trk receptors by neurotrophins in human neurons co‐expressing TrkB and TrkC
por: Ateaque, Sarah, et al.
Publicado: (2022)

Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome
por: Cao, Cong, et al.
Publicado: (2013)

Regulation of a TrkB Alternative Transcript by microRNAs
por: Wong, Jenny
Publicado: (2014)

TrkB/BDNF signalling patterns the sympathetic nervous system
por: Kasemeier-Kulesa, Jennifer C., et al.
Publicado: (2015)

Prenatal Cocaine Exposure Upregulates BDNF-TrkB Signaling
por: Stucky, Andres, et al.
Publicado: (2016)

Effects of palmatine on BDNF/TrkB-mediated trigeminal neuralgia
por: Liu, Lijuan, et al.
Publicado: (2020)

The Emerging Role of BDNF/TrkB Signaling in Cardiovascular Diseases
por: Hang, Peng-Zhou, et al.
Publicado: (2021)

Effect and mechanism of BDNF/TrkB signaling on vestibular compensation
por: Mao, Dehong, et al.
Publicado: (2021)

The BDNF/TrkB Neurotrophin System in the Sensory Organs of Zebrafish
por: Aragona, Marialuisa, et al.
Publicado: (2022)

Receptor-Independent Anti-Ferroptotic Activity of TrkB Modulators
por: Jakaria, Md., et al.
Publicado: (2022)

BDNF receptor TrkB as the mediator of the antidepressant drug action
por: Casarotto, Plinio, et al.
Publicado: (2022)

TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum
por: Nguyen, Huynh T. H., et al.
Publicado: (2019)

Evaluation of a TrkB agonist on spatial and motor learning in the Ube3a mouse model of Angelman syndrome
por: Schultz, Maria N., et al.
Publicado: (2020)

BDNF Outperforms TrkB Agonist 7,8,3′-THF in Preserving the Auditory Nerve in Deafened Guinea Pigs
por: Vink, Henk A., et al.
Publicado: (2020)

TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice
por: Qin, Xunsi, et al.
Publicado: (2022)

Artemin Is Upregulated by TrkB Agonist and Protects the Immature Retina Against Hypoxic-Ischemic Injury by Suppressing Neuroinflammation and Astrogliosis
por: Huang, Hsiu-Mei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_09gi9oe9tmjcvjnns5lp2qkrqt