Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus

BK polyomavirus (BKPyV) is an opportunistic pathogen that uses the b-series gangliosides GD1b and GT1b as entry receptors. Here, we characterize the impact of naturally occurring VP1 mutations on ganglioside binding, VP1 protein structure, and virus tropism. Infectious entry of single mutants E73Q a...

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Detalles Bibliográficos
Autores principales: Sorin, Marie N., Di Maio, Antonio, Silva, Lisete M., Ebert, Domenic, Delannoy, Clément P., Nguyen, Ngoc-Khanh, Guerardel, Yann, Chai, Wengang, Halary, Franck, Renaudin-Autain, Karine, Liu, Yan, Bressollette-Bodin, Céline, Stehle, Thilo, McIlroy, Dorian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989821/
https://www.ncbi.nlm.nih.gov/pubmed/36790933
http://dx.doi.org/10.1016/j.celrep.2023.112114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989821/
https://www.ncbi.nlm.nih.gov/pubmed/36790933
http://dx.doi.org/10.1016/j.celrep.2023.112114

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