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Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus
BK polyomavirus (BKPyV) is an opportunistic pathogen that uses the b-series gangliosides GD1b and GT1b as entry receptors. Here, we characterize the impact of naturally occurring VP1 mutations on ganglioside binding, VP1 protein structure, and virus tropism. Infectious entry of single mutants E73Q a...
Autores principales: | Sorin, Marie N., Di Maio, Antonio, Silva, Lisete M., Ebert, Domenic, Delannoy, Clément P., Nguyen, Ngoc-Khanh, Guerardel, Yann, Chai, Wengang, Halary, Franck, Renaudin-Autain, Karine, Liu, Yan, Bressollette-Bodin, Céline, Stehle, Thilo, McIlroy, Dorian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9989821/ https://www.ncbi.nlm.nih.gov/pubmed/36790933 http://dx.doi.org/10.1016/j.celrep.2023.112114 |
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