Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation

BACKGROUND: Major retinal degenerative diseases, including age-related macular degeneration, diabetic retinopathy and retinal detachment, are associated with a local decrease in oxygen availability causing the formation of hypoxic areas affecting the photoreceptor (PR) cells. Here, we addressed the...

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Detalles Bibliográficos
Autores principales: Todorova, Vyara, Stauffacher, Mia Fee, Ravotto, Luca, Nötzli, Sarah, Karademir, Duygu, Ebner, Lynn J. A., Imsand, Cornelia, Merolla, Luca, Hauck, Stefanie M., Samardzija, Marijana, Saab, Aiman S., Barros, L. Felipe, Weber, Bruno, Grimm, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990367/
https://www.ncbi.nlm.nih.gov/pubmed/36882871
http://dx.doi.org/10.1186/s13024-023-00602-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990367/
https://www.ncbi.nlm.nih.gov/pubmed/36882871
http://dx.doi.org/10.1186/s13024-023-00602-x

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