An anti-mesothelin targeting antibody drug conjugate induces pyroptosis and ignites antitumor immunity in mouse models of cancer

BACKGROUND: Emerging evidence suggests that the mechanism of chemotherapy-induced cell death may influence the antitumor immune response in patients with cancer. Unlike immunologically silent apoptosis, pyroptosis is a lytic and inflammatory form of programmed cell death characterized by pore format...

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Detalles Bibliográficos
Autores principales: Wittwer, Nicole L, Staudacher, Alexander H, Liapis, Vasilios, Cardarelli, Pina, Warren, Harriet, Brown, Michael P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990647/
https://www.ncbi.nlm.nih.gov/pubmed/36878534
http://dx.doi.org/10.1136/jitc-2022-006274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990647/
https://www.ncbi.nlm.nih.gov/pubmed/36878534
http://dx.doi.org/10.1136/jitc-2022-006274

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